Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Glucose-Insulin Model in Type 1 Diabetes
WIP From zenker 2007 article PLoS Computational Biology From Inverse Problems in Mathematical Physiology to Quantitative Differential Diagnoses
Cardiovascular Model
Bond Graph Kinetic Modeling Metabolic Map by J LeFevre http://www.systemdynamics.org/conferences/2004/SDS_2004/PAPERS/379LEFEV.pdf
See also IM-857 and IM-2235 for more detail
Michaelis Menten Enzyme Metabolic Map
Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Layout of insight IM-855 See also IM-2235 for unfolding version
Catalyzed Reaction (Michaelis Menten) 2
Addition of glucagon hormone action to control glucose homeostasis extended from IM-586
Glucose regulation CLD 2
Part of Urea Kinetic model for Clearance Experiments
Dialysis blood flow
Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.
V1 Glucose minimal model
Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Type 1 Diabetes
Addition of glucagon hormone action to control glucose homeostasis extended from IM-586
Clone of Glucose regulation CLD 2
ithink example from isee systems using receptors
Michaelis Menten Kinetics
WIP Thyroid HPA axis dynamics based on Kohanin 2022 article and Ch3.5 of Uri Alon's System Medicine book. A series of secrete and grow physiological circuits
Thyroid dynamics
Simplified version of IM-852 Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map Insight 810
Clone of ESA Dosing in Renal Anemia Simple Simulation
Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Clone of Clone of Glucose-Insulin Model in Type 1 Diabetes
Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Clone of Glucose-Insulin Model in Type 1 Diabetes
Simplified version of IM-852 Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map Insight 810
Clone of ESA Dosing in Renal Anemia Simple Simulation
From Tarek KA Hamid's Book Thinking in Circles About Obesity Springer 2009
Obesity Thinking in Circles
Explanation of delays in treatment effect and rebound effects on cessation of anti-depressant SSRI drugs based on Andrews
Anti-depressants and oppositional perturbation
From p592 Doyle F et al.(2007) Journal of Process Control 17 571-594
abstract
Heparin Kinetics
Bond Graph Kinetic Modeling Metabolic Map by J LeFevre http://www.systemdynamics.org/conferences/2004/SDS_2004/PAPERS/379LEFEV.pdf
See also IM-857 and IM-2235 for more detail
Clone of Michaelis Menten Enzyme Metabolic Map
Small Intestine example from Progress in Biophysics & Molecular Biology Special Issue 2016 From the century of the genome to the century of the organism: New theoretical approaches paper on organization. Compare with Bogdanov (click tag)
Biology Principles of Organization and Variation 1
Diagrams from Greene 2017 nejm article Putting the patient back together Social Medicine, Network Medicine, and the Limits of Reductionism
Network medicine
Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Alternate Layout of insight IM-857 Here Join and Split Flows are unfolded rather than using folders around the Stocks.
Catalyzed Reaction (Michaelis Menten) 2 with split and join
Addition of glucagon hormone action to control glucose homeostasis extended from IM-586
Clone of Clone of Glucose regulation CLD 2
