Addition of glucagon hormone action to control glucose homeostasis extended from IM-586
Clone of Clone of Glucose regulation CLD 2
Working model of Erythropoiesis and Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map Insight 810 and Simpler Dosing Model at IM-26182
ESA Dosing in Renal Anemia Simulation
Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Type 1 Diabetes
Bond Graph Kinetic Modeling Metabolic Map by J LeFevre http://www.systemdynamics.org/conferences/2004/SDS_2004/PAPERS/379LEFEV.pdf
See also IM-857 and IM-2235 for more detail
Clone of Michaelis Menten Enzyme Metabolic Map
Summary of Gizem Aktas M Sc thesis and prize winning paper from ISDC2018 extended
abstract pdf See also Tom fiddaman's metaSD blog entry1 and entry 2 Note the response time frame of interest is from hours to around 45 days. See IM-34861 for a broader developmental view
Stress Response Dynamics
Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Clone of Clone of Clone of Glucose-Insulin Model in Type 1 Diabetes
Dosage per day, Doses per day, Every ? hours, Medicine in Intestines, Drug absorption, Plasma level, Blood volume, Plasma concentration, Toxic level, Medicinal level, Drug excretion, Excretion rate, Half-Life
Pharmacokinetics
Additional of glucagon hormone action to control glucose homeostasis
Clone of Glucose regulation CLD 2
A simple glucose regulation causal loop diagram taken from Richard O. Foster, 1970: The Dynamics of blood sugar regulation, MSc thesis, MIT Dept of Electrical Engineering, available on the MIT System Dynamics Group Literature Collection and in the MIT Electronic Libraries. See IM-587 for Addition of Glucagon
Clone of Glucose regulation CLD 1
Simplified version of IM-852 Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map Insight 810
Clone of ESA Dosing in Renal Anemia Simple Simulation
Simplified version of IM-852 Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map Insight 810
Clone of ESA Dosing in Renal Anemia Simple Simulation
Simplified version of IM-852 Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map Insight 810
Clone of ESA Dosing in Renal Anemia Simple Simulation
Protein conformance change based on Ed Gallaher and Jim Rogers 2021 Forrester Award Lecture ISDC
Protein Dynamics
Examples of macroanalysis relevant to representing causal mechanisms linking genes to diseases from darden2018 MecCog article and 2017 Product to Process article
Mechanistic Reasoning from Genotype to Phenotype
Part of Urea Kinetic model for Clearance Experiments
Dialysis blood flow
Periodic table of disease patterns and physiological circuits from Ch 9 of Uri Alon's System Medicine Book Circuit motifs are modified to facilitate building system dynamics simulations
System Medicine Physiological Circuits Disease Patterns
System Zoo Z111 H Bossel p47 a variant of Michaelis Menten Enzyme Kinetics. See also IM-854 for Hannon and Ruth and IM-855 for receptor version and IM-856 for a bond graph view
Density Dependent Growth (Michaelis-Menten)
Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Clone of Clone of Glucose-Insulin Model in Type 1 Diabetes
Bond Graph Kinetic Modeling Metabolic Map by J LeFevre http://www.systemdynamics.org/conferences/2004/SDS_2004/PAPERS/379LEFEV.pdf
See also IM-857 and IM-2235 for more detail
Clone of Michaelis Menten Enzyme Metabolic Map
Bond Graph Kinetic Modeling Metabolic Map by J LeFevre http://www.systemdynamics.org/conferences/2004/SDS_2004/PAPERS/379LEFEV.pdf
See also IM-857 and IM-2235 for more detail
Clone of Michaelis Menten Enzyme Metabolic Map
Part of Urea Kinetic model for Clearance Experiments
Clone of Clone of Dialysis blood flow
Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Alternate Layout of insight IM-857 Here Join and Split Flows are unfolded rather than using folders around the Stocks.
Clone of Catalyzed Reaction (Michaelis Menten) 2 with split and join
Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.
Glucose minimal model Cambio#1
