Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

Sign graph model representing some of the dynamic relationships that exist in relation to diabetic patients and resulting impacted medical professions

Jones AP, Homer JB, Murphy DL, Essien JDK, Milstein B, Seville DA.

Understanding diabetes population dynamics through simulation modeling

and experimentation. American Journal of Public Health 2006;96(3):488-494.

http://ajph.aphapublications.org/cgi/content/abstract/96/3/488

Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

WIP example of Services oriented multiscale computable narrative synthesis focussed on Coping carefully with diabetes

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

DIabetes incidence from population inflow, with undiagnosed and diagnosed stocks

This three loop goal-seeking structure identifies the three key influences on managing blood glucose for people with diabetes - insulin injections reduce blood glucose levels, exercise reduces blood glucose levels, and food increases blood glucose levels.  The balance of all three is necessary to manage diabetes.

DIabetes incidence inflow, Prevalence stock and deaths outflow

Addition of glucagon hormone action to control glucose homeostasis extended from IM-586

Additional of glucagon hormone action to control glucose homeostasis

Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker

Glucose Insulin Model Info:

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

WIP example of Services oriented multiscale computable narrative synthesis focussed on Coping carefully with diabetes

DIabetes incidence inflow, Prevalence stock and deaths outflow

Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.

A simple glucose regulation causal loop diagram taken from Richard O. Foster, 1970: The Dynamics of blood sugar regulation, MSc thesis, MIT Dept of Electrical Engineering, available on the MIT System Dynamics Group Literature Collection and in the MIT Electronic Libraries. See IM-587 for Addition of Glucagon

Jones AP, Homer JB, Murphy DL, Essien JDK, Milstein B, Seville DA.

Understanding diabetes population dynamics through simulation modeling

and experimentation. American Journal of Public Health 2006;96(3):488-494.

http://ajph.aphapublications.org/cgi/content/abstract/96/3/488