Working model of Erythropoiesis and Erythropoiesis Stimulating Agents (ESA) Dosing in Anemia due to Renal Failure from Jim Rogers See Stock Flow Map Insight 810 and Simpler Dosing Model at IM-26182
Dosage per day, Doses per day, Every ? hours, Medicine in Intestines, Drug absorption, Plasma level, Blood volume, Plasma concentration, Toxic level, Medicinal level, Drug excretion, Excretion rate, Half-Life
Mammary gland structures example from Progress in Biophysics & Molecular Biology Special Issue 2016 From the century of the genome to the century of the organism: Montevil paper on organogenesis. Compare with Bogdanov (click tag)
Examples of macroanalysis relevant to representing causal mechanisms linking genes to diseases from darden2018 MecCog article and 2017 Product to Process article
Hannon and Ruth Modeling Dynamic Biological Systems p67 adapted to Bond Graph Kinetic Modeling Metabolic Map Alternate Layout of insight IM-857 Here Join and Split Flows are unfolded rather than using folders around the Stocks.
Stock flow map of Immune System Cell type proliferation and differentiation, migration and circulation from Figs 1.3, 8.14 and 8.33 from Janeway's Immunobiology see Insight . Does not include cell death, interactions or inhibitory and promoting factors
Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.
Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.
Summary of Gizem Aktas M Sc thesis and prize winning paper from ISDC2018 extended abstract pdf
See also Tom fiddaman's metaSD blog entry1 and entry 2 Note the response time frame of interest is from hours to around 45 days. See IM-34861 for a broader developmental view
Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.
Dosage per day, Doses per day, Every ? hours, Medicine in Intestines, Drug absorption, Plasma level, Blood volume, Plasma concentration, Toxic level, Medicinal level, Drug excretion, Excretion rate, Half-Life