WIP based on WHO Decade of Healthy Ageing baseline report 2020 Annex
WHO Healthy Ageing
Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Type 1 Diabetes
Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here
Clone of Depression Dynamics
Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here. See also 2018 N. Hosseinichimeh Plos ONE article for rumination focussed SD simulation
Clone of Clone of Depression Dynamics
Summary of Gizem Aktas M Sc thesis and prize winning paper from ISDC2018 extended
abstract pdf See also Tom fiddaman's metaSD blog entry1 and entry 2 Note the response time frame of interest is from hours to around 45 days. See IM-34861 for a broader developmental view
Stress Response Dynamics
Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Clone of Clone of Clone of Glucose-Insulin Model in Type 1 Diabetes
Additional of glucagon hormone action to control glucose homeostasis
Clone of Glucose regulation CLD 2
Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here
Clone of Depression Dynamics
A simple glucose regulation causal loop diagram taken from Richard O. Foster, 1970: The Dynamics of blood sugar regulation, MSc thesis, MIT Dept of Electrical Engineering, available on the MIT System Dynamics Group Literature Collection and in the MIT Electronic Libraries. See IM-587 for Addition of Glucagon
Clone of Glucose regulation CLD 1
Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here
Clone of Depression Dynamics
Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here
Clone of Depression Dynamics
WIP for Nutrition and the first 1000 days
Nutrition and Early Childhood Development
WIP representation of thinking feeling acting and interacting
Clone of Human behaviour
Protein conformance change based on Ed Gallaher and Jim Rogers 2021 Forrester Award Lecture ISDC
Protein Dynamics
Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here. See also 2018 N. Hosseinichimeh Plos ONE article for rumination focussed SD simulation
Clone of Depression Dynamics
Double loop PCT IM-9007 extended to show hierarchical PCT and goal conflict psychotherapy. A simulation structure for IM-233044 See also a Suicide crisis and PCT IM-173189 simulation structure
Hierarchical Perceptual Control Theory and Psychotherapy
Periodic table of disease patterns and physiological circuits from Ch 9 of Uri Alon's System Medicine Book Circuit motifs are modified to facilitate building system dynamics simulations
System Medicine Physiological Circuits Disease Patterns
Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here. See also 2018 N. Hosseinichimeh Plos ONE article for rumination focussed SD simulation
Clone of Depression Dynamics
Created in James Madison University's ISAT 341 Simulation and Modeling course by Joseph Straub and Andrew Funkhouser. Based on Mark Heffernan's Glucose-Insulin Insight Maker
Glucose Insulin Model Info:
Translated from Hormone.stm in Dynamic Modeling in the Health Sciences James L hargrove, Springer 1998, Ch 24 p255-261, by Mark Heffernan.
Clone of Clone of Glucose-Insulin Model in Type 1 Diabetes
Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here. See also 2018 N. Hosseinichimeh Plos ONE article for rumination focussed SD simulation
Clone of Depression Dynamics
Nested multiscale structures, functions and interactions based on Christian Moore Anderson biogogy blog entries
Biology Concept Maps
Based on Psychological Medicine Dec 2015 article Depression as a systemic syndrome: mapping the feedback loops of major depressive disorder by A. K. Wittenborn, H. Rahmandad, J. Rick and N. Hosseinichimeh, mentioned here. See also 2018 N. Hosseinichimeh Plos ONE article for rumination focussed SD simulation
Clone of Depression Dynamics
Minimal model of glucose kinetics by Bergman, used to calculate insulin sensitivity from an Intravenous Glucose Tolerance Test (IVGTT). Plasma insulin I(t) enters a remote compartment X(t) where it is active in accelerating glucose G(t) disappearance into the periphery and liver, and inhibiting hepatic glucose production. Adapted from Minimal Models for Glucose and Insulin Kinetics: A Matlab implementation by Natal van Riel, Eindhoven University of Technology 2004 by Mark Heffernan.
Glucose minimal model Cambio#1
